Its creator, J. Michael Straczynski, is fan of Lovecraft (and wrote one of the Lovecraft inspired Ghostbusters episodes)
The show is littered with references to the "first ones", ancient and awesomely powerful aliens far beyond humanitie's understanding.
He also introduced a Cthulhu like race called Pak'ma'ra
He used the name Charles Dexter for a character who has both a good and evil side (the good side being called Charles)
The Justice League animated series had an episode called "The Terror Beyond" involving tentacled sea monsters breaching our dimension and the team must cross over to attack the other worldly beings where they live.
The Adult Swim show Rick and Morty also features Cthulhu in the title sequence.
Macabre Massachusetts by comic artist Victor Laube contains many references to H. P. Lovecraft's Cthulhu mythos.
The town wherein the events of the comic book series Locke & Key by Joe Hill take place is named "Lovecraft, Massachusetts."
The "Ogdru Jahad", antagonists from Mike Mignola's Hellboy comic book series, are partially inspired by Lovecraft's "Great Old Ones."
The comic book series The League of Extraordinary Gentlemen by Alan Moore and Kevin O'Neill, set in a universe where many characters from popular fiction co-exist, Cthulhu has been referenced, although his name has been spelled "Kutulu", and a character has misheard his name as "cool Lulu".
Blue Oyster Cult: The Old Gods Return from the 2001 album Curse of the Hidden Mirror.
Metallica: The Call Of Ktulu from The 1984 album Ride The Lightning, The Thing that should not be From the 1986 album Master of Puppets, All Nightmare Long from the 2008 album Death Magnetic, and Dream No More from the 2016 album Hardwired...to Self-Destruct.
An Xbox/PC game placing the player in the role of a police man investigating the strange occurrences involving Old Ones cults and mostly notable placing the player inside the Lovecraft short story the Shadow over Innsmouth.
The Lurking Horror (Infocom)
Interactive fiction in which the player investigates weird happenings at G.U.E. University.
Alone in the Dark (I Motion) The first game of this classic horror series is strongly based on Lovecraft. Several tomes mention Cthulhoid beings and places, as well as appearances by the Deep Ones.
Shadow of the Comet (Interplay)
The first of what was supposed to be a series of "Call of Cthulhu" games, the player investigates the influence a fallen comet has on a town.
Prisoner of Ice (I Motion)
The player is a government agennt during WWII, thrawting a Nazi plan to raise Cthulhu as their weapon.
Dr Floyd's Desktop Games (Micropose)
Call of Duty: Black Ops 3
The Zombies map "Shadows of Evil" is large based on Lovecraft's world.
Demonbane - a Japanese eroge based on the Cthulhu mythos
Featured Shub-Niggurath as the final boss, and levels such as the Vaults of Zin and The Nameless City. Sandy Peterson was a level designer.
Terraria: Many of the bosses in the game are named after some part of Cthulhu's anatomy, e.g. "Eye of Cthulhu", "Brain of Cthulhu".
The game's final boss, Moon Lord, resembles common depictions of Cthulhu.